ligase amplification reaction
- ligase amplification reaction
-
Method for detecting small quantities of
a target DNA, with utility similar to
PCR. It relies on
DNA ligase to join adjacent synthetic oligonucleotides after they have bound the target DNA. Their small size means that they are destabilised by single base mismatches, and so form
a sensitive test for the presence of mutations in the target sequence.
Dictionary of molecular biology.
2004.
Look at other dictionaries:
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